Nathalie | Cancer research | Women Researcher Award

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Dr. Nathalie – Cancer research – Women Researcher Award

Alignment with Award Category

Dr. Mazure’s groundbreaking research in cancer biology, particularly her work on metabolic shifts in cancer cells and the molecular mechanisms of cell death resistance, aligns perfectly with the award category recognizing excellence in scientific research in the field of cancer biology. Her contributions to understanding cancer metabolism, hypoxia, and the role of primary cilia in tumor survival have had far-reaching implications for cancer treatment and drug development.

 

CNRS | France

Profile
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🎓Early Academic Pursuits 

Education and Training

Nathalie Mazure was born on July 8, 1966, in Issy-les-Moulineaux, France. Her academic journey began with a strong foundation in biological sciences. She earned her PhD in 1994 from the University of Technology of Compiègne, focusing on microbial genetics. This early research sparked her passion for exploring the molecular mechanisms underlying cellular functions, which would later become the central theme of her academic and professional pursuits.

💼Professional Endeavors 

Academic Positions

Dr. Mazure’s career spans multiple academic and research positions, primarily centered around cancer research, molecular biology, and cellular metabolism. Since January 2024, she has been co-directing Team 5 “Cancer, Metabolism and Microenvironment” at the Institut C3M (INSERM U1065) and the University of Nice-Sophia Antipolis. Her research theme focuses on critical areas such as cancer, cell death resistance, hypoxia, and the role of VDAC1 and primary cilium in these processes.

📚Contributions and Research Focus on Cancer research

Dr. Mazure’s research has been pivotal in exploring the molecular mechanisms involved in cancer progression, particularly in how tumor cells survive in low-oxygen (hypoxic) environments. Her work on VDAC1, a mitochondrial protein, has led to significant insights into cell death resistance in cancer cells. The development of a predictive biomarker for chemoresistance, based on the molecular interactions between VDAC1 and other cellular components, is one of her notable contributions. In addition to her work on cancer cell metabolism, Dr. Mazure has been a key figure in advancing our understanding of primary cilium function in cancer cells. This organelle, often overlooked in traditional cancer research, plays a critical role in cellular signaling pathways that regulate cell growth and survival. Her interdisciplinary approach, combining cell biology, molecular genetics, and cancer research, has led to a deeper understanding of the metabolic shifts that occur in cancer cells under stress.

🏆Accolades and Recognition 

Throughout her illustrious career, Dr. Mazure has received numerous accolades, underscoring her significant contributions to cancer research. She was awarded the prestigious Laureate prize from the Fondation Aventis in 2001 for her innovative research in human health. She was also the recipient of the Madeleine and Jean Schaeverbeke Prize in 2010, awarded by the Fondation de France, recognizing her exceptional work in cancer biology.

🌍 Impact and Influence 

Community Impact

Dr. Mazure’s research has had a profound impact on both the scientific community and clinical applications. Her discoveries related to cancer cell metabolism and resistance to cell death have opened new avenues for therapeutic interventions targeting the metabolic pathways that tumors exploit for survival. Her work has influenced cancer therapies, particularly those aimed at overcoming resistance to chemotherapy and improving the efficacy of existing treatments.

🔮Legacy and Future Contributions 

As Dr. Mazure continues to lead her research team at C3M, her future contributions are poised to shape the next generation of cancer therapies. Her current focus on the interplay between cancer metabolism and the immune system, as well as her ongoing efforts to understand the role of hypoxia in cancer progression, will likely lead to the development of more targeted and personalized cancer treatments.

Conclusion

Nathalie Mazure’s career has been defined by a relentless pursuit of scientific knowledge, a commitment to improving cancer treatments, and a strong dedication to fostering international collaborations. Through her research, leadership, and mentoring, she has made a significant impact on the field of cancer biology and beyond. As she continues to push the boundaries of scientific discovery, her legacy will undoubtedly inspire future generations of researchers and clinicians dedicated to improving human health

📚Publications

YAP1 modulation of primary cilia‐mediated ciliogenesis in 2D and 3D prostate cancer models

Authors: Yingbo Guo; Mathilde Dupart; Marie Irondelle; Pascal Peraldi; Frederic Bost; Nathalie M. Mazure
Journals: FEBS Letters

CXCR4 signaling determines the fate of hematopoietic multipotent progenitors by stimulating mTOR activity and mitochondrial metabolism

Authors: Vincent Rondeau; Maria Kalogeraki; Lilian Roland; Zeina Abou Nader; Vanessa Gourhand; Amélie Bonaud; Julia Lemos; Mélanie Khamyath; Clémentine Moulin; Bérénice Schell et al.
Journals: Science Signaling

Vitiligo auto‐immune response upon oxidative stress‐related mitochondrial DNA release opens up new therapeutic strategies

Authors: Ana Sant’Anna-Silva; Thomas Botton; Andrea Rossi; Jochen Dobner; Hanene Bzioueche; Nguyen Thach; Lauriane Blot; Sophie Pagnotta; Konrad Kleszczynski; Kerstin Steinbrink et al.
Journals: Clinical and Translational Medicine

Veit Phillip | Medicine | Best Researcher Award

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Assoc Prof Dr. Veit Phillip – Medicine – Best Researcher Award

Leadership and Professional Roles:

Dr. Phillip holds a senior position as a physician at the Klinikum rechts der Isar, Technical University of Munich, where he leads the interdisciplinary pancreas conference, showcasing his leadership and expertise in clinical settings. His membership in several professional societies and editorial boards, such as the German Society for Internal Medicine and the Editorial Board of “Gastroenterology Review,” highlights his influence and standing in the medical community.

TUM School of Medicine and Health, Technical University of Munich | Germany

Profiles 

Scopus

📍Current Position

Dr. med. Veit Thomas Phillip currently holds the position of Senior Physician at the Clinic and Polyclinic for Internal Medicine II at Klinikum rechts der Isar, Technical University of Munich. He has been serving in this role since October 2019, where he oversees patient care, contributes to medical research, and leads the interdisciplinary pancreas conference (“Pancreas Board”) initiated in October 2018. His responsibilities also include mentoring junior doctors, collaborating with other specialists, and managing complex cases in internal medicine and gastroenterology.

📝Publication Achievements 

Journals Published

“I am losing weight unintentionally.” (2024) – A paper exploring unintentional weight loss in gastroenterology patients, published in MMW Fortschr Med. “Gut microbiota predicts severity and reveals novel metabolic signatures in acute pancreatitis.” (2023) – A significant study in Gut that examines the relationship between gut microbiota and the severity of acute pancreatitis. “Comparison of endoscopic ultrasound-guided fine-needle aspiration and fine-needle biopsy to generate pancreatic cancer organoids: Randomized trial.” (2024) – Published in Endosc Int Open, this research compares biopsy methods in pancreatic cancer diagnosis.

 🔍Ongoing Research 

Dr. Phillip is deeply involved in ongoing research projects focusing on the epidemiology and treatment of acute pancreatitis, pancreatic cancer, and the role of microbiota in gastrointestinal diseases. His research aims to improve diagnostic accuracy, patient outcomes, and the understanding of disease mechanisms. One of his notable projects is a randomized trial comparing endoscopic ultrasound-guided biopsy techniques for pancreatic cancer, which has the potential to revolutionize diagnostic procedures in oncology.

 🔬Research Interests 

Gastroenterology: Specializing in pancreatitis, pancreatic cancer, and gastrointestinal disorders. Microbiota: Exploring the gut microbiota’s role in gastrointestinal diseases and its potential as a therapeutic target. Medical Imaging: Advancing imaging techniques in gastroenterology, particularly in the early detection of pancreatic lesions. Machine Learning: Integrating AI and machine learning into clinical practice to enhance diagnostic accuracy and treatment planning.

🎓Academic Background 

Dr. Phillip’s academic journey began at Camerloher-Gymnasium Freising, where he completed his general higher education entrance qualification in 1998. He pursued human medicine at the Justus-Liebig University of Giessen (2000-2002) and continued his studies at the University of Regensburg, where he completed his state examination in 2006. His academic achievements include a doctoral degree (Dr. med.) in 2007, with a dissertation on interferon-α’s role in experimental colitis, earning the distinction magna cum laude. He further specialized in internal medicine and gastroenterology, achieving multiple certifications, including a postdoctoral lecture qualification in 2017.

 🏆Scholarships and Awards 

Research Funding (2010): Awarded by the Kuratorium für Klinische Forschung, Technical University of Munich, for his project on liver disease and transplantation, with a grant of €60,000. Abraham Vater Prize for Clinical Pancreas Research: Received twice (2012, 2014) for his groundbreaking work in pancreatology. Colorectal Cancer Prevention Prize 2024: Awarded by the LebensBlicke Foundation, recognizing his contributions to cancer prevention research.

 🌐Professional Associations 

German Society for Internal Medicine: Member since 2010, contributing to the field of internal medicine through research and clinical practice. Society for Gastroenterology in Bavaria: Member since 2008, where he collaborates with other specialists to advance gastroenterology in the region. German Pancreas Club: A member since 2013, actively participating in research and discussions related to pancreatic diseases.

 📚Training & Workshops 

Dr. Phillip regularly participates in training sessions and workshops to stay updated with the latest medical advancements. His certifications in genetic counseling, radiation protection, and nutrition reflect his dedication to continuous professional development.

 🎤Oral Presentations 

Dr. Phillip has delivered numerous oral presentations at national and international conferences, sharing his research findings on gastroenterology, pancreatology, and internal medicine. His ability to communicate complex medical concepts effectively has earned him recognition as a leading expert in his field.

 🧑‍🔬Tasks Completed as a Researcher 

As a researcher, Dr. Phillip has completed various tasks, including conducting clinical trials, publishing scientific papers, mentoring junior researchers, and leading interdisciplinary research teams. His work has significantly contributed to the understanding of gastrointestinal diseases and the development of new diagnostic and therapeutic approaches.

 🚀Success Factors 

Dr. Phillip attributes his success to a combination of rigorous academic training, continuous learning, collaboration with experts across disciplines, and a passion for improving patient care. His ability to integrate research into clinical practice has been a key factor in his professional achievements.

 🧪Publications & Laboratory Experience

Dr. Phillip’s laboratory experience includes working on cutting-edge research in gastroenterology, particularly in the study of pancreatitis and pancreatic cancer. His publications in prestigious journals are a testament to his expertise and contributions to medical science.

📚Publications: