DEROSA LISA | IMMUNOLOGY ONCOLOGY | Best Researcher Award

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Assist Prof Dr. DEROSA LISA – IMMUNOLOGY ONCOLOGY – Best Researcher Award 

GUSTAVE ROUSSY | France

Author Profile 

Early Academic Pursuits 🎓

She, MD, PhD, began her academic journey with a deep passion for medicine and oncology. She completed her MD at Pisa University in 2008, followed by a qualifying examination and registration as a physician in Italy in 2009. He pursued a specialty in medical oncology at Pisa University, achieving board certification in 2014. Her dedication to advancing her knowledge led her to complete an M2 in Pharmacology, Clinical Trial in Oncology at Pisa University in 2015. She further enhanced her expertise with a European University Diploma in Translational and Clinical Research in Oncology (DUERTECC) from Paris-Sud University in 2016, and a University Diploma in Animal Experimentation from Sorbonne University in 2018.

In 2019, he earned her PhD in Immunology from Paris-Sud University. Her academic excellence was further recognized when she became an Associate Professor of Immunology at Paris-Saclay University in 2023.

 Professional Endeavors 💼

Her professional career is marked by her commitment to cancer research and patient care. She holds several key positions at the prestigious Gustave Roussy Cancer Center (GRCC) in Villejuif-Grand Paris, France. As the Clinical Director of the ClinicObiome Cancer Immunology Department, she oversees groundbreaking programs focused on the interplay between the gut microbiome and cancer immunotherapy. She also serves as a Senior Specialist in Medical Oncology and a Research Associate in the U1015 Cancer Immunology Department at GRCC.

In addition to her roles at GRCC, she is an Associate Professor of Immunology at the Medical School of Paris-Saclay University. Her specialty lies in tumor immunology and cancer immunotherapy, where she has made significant contributions since 2016.

Contributions and Research Focus on IMMUNOLOGY ONCOLOGYđź“š

Her research focuses on the immunosuppressive effects of antibiotics in cancer immunotherapy and the role of gut microbiota in regulating antitumor immunity. She has pioneered several concepts in this field, demonstrating how gut microbiota composition can influence the efficacy of immune checkpoint inhibitors. Her work has been widely published, with over 100 papers indexed on PubMed, including multiple contributions to high-impact journals such as Nature Medicine, Cell, and Cancer Discovery. Her impressive H-factor of 38 and 8,515 citations underscore her influence and the importance of her research in the scientific community.

Accolades and Recognition 🏆

Throughout her career, she has received numerous prestigious awards and honors, highlighting her contributions to oncology and immunology. Notable awards include multiple Merit Awards from the American Society of Clinical Oncology (ASCO) and the European Society for Medical Oncology (ESMO). In 2023, she received the Conquer Cancer Foundation ASCO Merit Award. Other significant recognitions include the Best Scientific Paper Award from European Urology in 2021 and the EATI Award in 2020.

 Impact and Influence 🌍

Her work has had a profound impact on the field of cancer immunotherapy. Her research on the gut microbiome’s role in cancer treatment has opened new avenues for understanding and enhancing the efficacy of immunotherapy. She leads the Microbiota-centered intervention program (ClinicObiome) at GRCC and co-directs significant clinical programs such as the RHU Clinical Program Grant “Immunolife” and the EU Program Grant “Oncobiome”. These programs aim to develop innovative strategies for cancer treatment based on her groundbreaking research.

 Legacy and Future Contributions 🔮

Her legacy in the field of oncology and immunology is marked by her pioneering research and significant contributions to cancer treatment. Her ongoing work continues to push the boundaries of medical science, offering new hope for cancer patients worldwide. As she advances in her career, she is poised to make even greater strides in understanding and leveraging the immune system’s role in cancer therapy. Her dedication to research, patient care, and education ensures that her impact will be felt for generations to come.

Notable Publications 

  1. Gut microbiome influences efficacy of PD-1–based immunotherapy against epithelial tumors
  2. Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer
  3. Elevated calprotectin and abnormal myeloid cell subsets discriminate severe from mild COVID-19
  4. Combination chemotherapy versus melphalan plus prednisone as treatment for multiple myeloma: an overview of 6,633 patients from 27 randomized trials
  5. Cross-tissue single-cell landscape of human monocytes and macrophages in health and disease
  6. Intestinal Akkermansia muciniphila predicts clinical response to PD-1 blockade in patients with advanced non-small-cell lung cancer
  7. The detection of androgen receptor splice variant 7 in plasma-derived exosomal RNA strongly predicts resistance to hormonal therapy in metastatic prostate cancer patients
  8. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade
  9. Cross-reactivity between tumor MHC class I–restricted antigens and an enterococcal bacteriophage

Tengda Li | IMMUNOLOGY | Best Researcher Award 

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Dr. Tengda Li – IMMUNOLOGY – Best Researcher Award 

Wenzhou medical university  |  China

Author Profile 

Early Academic Pursuits 🎓

She originally from Qingxian, Cangzhou, Hebei Province, embarked on her academic journey with a bachelor’s degree in Medical Laboratory Science from the Medical College of Hunan Normal University. Her early education laid a strong foundation in the biological sciences, fostering a deep interest in medical research. This interest propelled her towards advanced studies, leading to her current pursuit of a PhD in Immunology at the prestigious Peking Union Medical College.

 Professional Endeavors 💼

Throughout her academic and professional career, she has demonstrated exceptional dedication and skill in the field of immunology and medical diagnostics. Her research has spanned several critical areas, showcasing her versatility and depth of knowledge.

  1. Research on LKB1 in Macrophage Homeostasis and Self-renewal: Her groundbreaking work in macrophage homeostasis has been pivotal. She discovered that LKB1 is crucial for maintaining metabolic and immune balance within macrophages. Her findings, which highlighted the vulnerability of lungs to infections like Staphylococcus aureus in the absence of LKB1, were published in Frontiers in Immunology (2021, IF=8.786), where she served as a co-first author.
  2. Research on Autoimmune Diseases and Digestive System Disorders: Her exploration into autoimmune diseases has uncovered novel immune molecules associated with primary biliary cholangitis (PBC) and psoriasis. These findings, published in Microbiology and Immunology (2018, IF=2.962) and Tohoku Journal of Experimental Medicine (2018, IF=2.547), provided new insights into the Th1/Th2/Treg cell immune function. Additionally, her work on the epigenetic regulation of digestive system diseases, published in Clinical Epigenetics (2020, IF=7.259), emphasized the role of DNA methylation.
  3. Development of Novel Disease Marker Detection Methods Based on SERS Technology: she pioneered a new method for detecting disease markers on exosomes using PEARL-structured SERS probes. This innovative approach was detailed in Chemical Science (2018, IF=9.969) and has gained significant recognition, with 156 citations from leading international journals.
  4. Bioinformatics Research: Through her analysis of over 400 methylation samples of gastric cancer and melanoma, she established prognostic models and explored m6A regulatory genes’ diagnostic value in melanoma. These studies, resulting in three SCI papers, underscored her expertise in bioinformatics and computational biology.

Contributions and Research Focus on IMMUNOLOGY đź“š

Her primary research focuses on autoimmune diseases and tumor immunology, specifically in the discovery of disease diagnostic markers and the development of novel diagnostic methods. Her work in constructing predictive models has been particularly influential. To date, she has published 15 SCI papers, reflecting her prolific contribution to the scientific community.

 Accolades and Recognition 🏆

Her achievements have not gone unnoticed. Her work has received acclaim in various high-impact journals, and her innovative methodologies have been widely cited and utilized by other researchers. This recognition speaks volumes about her impact and the respect she commands in the field of immunology and diagnostics.

 Impact and Influence 🌍

Her research has had a profound impact on the scientific community and beyond. Her studies on LKB1 have advanced our understanding of macrophage biology, while her work on autoimmune diseases has provided new therapeutic targets. The novel diagnostic methods she developed using SERS technology have the potential to revolutionize how diseases are detected and monitored, making diagnostics more accurate and efficient.

 Legacy and Future Contributions 🔮

As she continues her PhD studies, her future contributions are eagerly anticipated. Her work thus far suggests a promising trajectory, with potential breakthroughs in autoimmune disease treatment and tumor immunology. Her legacy will likely include significant advancements in both experimental and computational methods in medical research.

Notable PublicationsÂ