Dr. Linghui Qian – Fluorescent imaging – Best Researcher Award
Alignment with Award Category
Professor Qian’s multidisciplinary research, innovation in probe development and imaging technology, and impact on both fundamental science and therapeutic applications align strongly with the objectives of the Best Researcher Award and Excellence in Innovation category. Her achievements reflect not only high scholarly productivity but also pioneering contributions to biomedical science and engineering
Zhejiang University | China
Profile
🎓Early Academic Pursuits
Education and Training
Linghui Qian’s journey into the world of pharmaceutical sciences began with her undergraduate education at Zhejiang University, one of China’s most prestigious institutions. From September 2008 to June 2012, she pursued a Bachelor of Science in Pharmaceutical Science at the College of Pharmaceutical Sciences. During this period, she cultivated a strong foundation in drug metabolism and pharmaceutical analysis, which would later define her research trajectory. Under the mentorship of Prof. Su Zeng, she explored fundamental principles that underpin the development of chemical tools used in biomedical research. Driven by a passion for scientific inquiry, Linghui Qian advanced her studies internationally. In January 2013, she enrolled in the National University of Singapore (NUS) for a Ph.D. in Chemical Biology at the Department of Chemistry. Under the guidance of Prof. Shao Qin Yao, she worked on interdisciplinary projects that bridged chemistry and biology, especially focusing on chemical tools to probe biological systems. Her doctoral research laid the groundwork for her interest in the development of fluorescent probes and the functionalization of antibodies for disease-targeted applications.
💼Professional Endeavors
Academic Positions
Following her Ph.D., Linghui Qian undertook several impactful research roles that broadened her scientific perspective and allowed her to apply her academic learnings in cutting-edge research environments. Between January 2017 and August 2017, she served as a Research Assistant at the Department of Chemistry, NUS, continuing to collaborate with Prof. Shao Qin Yao. She deepened her understanding of live-cell imaging, biomolecular detection, and the modulation of biological processes using synthetic tools. From September 2017 to September 2018, she moved to Singapore’s A*STAR (Agency for Science, Technology and Research), where she held the position of Research Fellow at the Institute of Molecular and Cell Biology. Under the supervision of Prof. Haiwei Song, she expanded her research scope, delving into molecular mechanisms of disease and exploring ways to harness chemical biology for therapeutic applications. In November 2018, she returned to her alma mater, Zhejiang University, as a tenure-track Research Professor at the College of Pharmaceutical Sciences. This appointment marked the beginning of a new chapter in her professional journey, where she leads independent research and mentors the next generation of scientists.
📚Contributions and Research Focus on Fluorescent imaging
Linghui Qian is recognized for her significant contributions to chemical biology and pharmaceutical sciences. Her research focuses on the development and application of innovative chemical probes to detect and study biomacromolecules in live systems. These tools are critical in understanding complex biological phenomena, especially those related to disease. Her work is particularly centered on Development of fluorescent probes for live-cell imaging and Functionalization of antibodies for therapeutic applications In addition to tool development, she also explores chemical strategies to regulate biological processes, which has implications for drug development and disease treatment.
🏆Accolades and Recognition
Though specific awards are not listed in the provided content, Linghui Qian’s rapid career progression—from Ph.D. candidate to Research Professor—within a span of less than a decade speaks volumes about the recognition of her expertise within the academic and scientific communities. Being appointed to a tenure-track position at Zhejiang University, one of China’s top research institutions, reflects her standing as a leading researcher in her field.
🌍 Impact and Influence
Community Impact
Linghui Qian’s work resides at the intersection of chemical innovation and biological discovery, a space increasingly vital in addressing global health challenges. Her research on chemical probes contributes to a deeper understanding of disease biology, while her advances in antibody functionalization hold potential for therapeutic innovation. Moreover, her experience across top institutions—Zhejiang University, NUS, and A*STAR—demonstrates her global influence and collaboration. As a mentor and educator, she shapes the future of pharmaceutical sciences, fostering interdisciplinary research among students and colleagues.
🔮Legacy and Future Contributions
Publications
A modular artificial intelligence framework to facilitate fluorophore design
Authors: Yuchen Zhu; Jiebin Fang; Shadi Ali Hassen Ahmed; Tao Zhang; Su Zeng; Jia-Yu Liao; Zhongjun Ma; Linghui Qian
Journals: Nature Communications
Catalytic stereodivergent and simultaneous construction of axial and point chirality
Authors: Wen-Tao Wang; Sen Zhang; Wenxuan Lin; Zhang-Hong Luo; Dan Hu; Fen Huang; Ruopeng Bai; Yu Lan; Linghui Qian; Jia-Yu Liao
Journals: Organic Chemistry Frontiers
Autophagy‐Mediated Targeted Protein Degradation
Authors: Jinning Shao; Shangzhi Xie; Shurui Hong; Linghui Qian
Journals: ChemMedChem
Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen
Authors: Zai-Gang Han; Kaifeng He; Yi Zheng; Linghui Qian
Journals: Organic & Biomolecular Chemistry
Antibody-based near-infrared fluorogenic probes for wash-free imaging of cell-surface proteins
Authors: Haoting Wang; Jiaqi Yan; Wenchao Wang; Endong Chen; Di Chen; Su Zeng; Quan Li; Linghui Qian