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Dr. Linghui Qian –  Fluorescent imaging – Best Researcher Award

Alignment with Award Category

Professor Qian’s multidisciplinary research, innovation in probe development and imaging technology, and impact on both fundamental science and therapeutic applications align strongly with the objectives of the Best Researcher Award and Excellence in Innovation category. Her achievements reflect not only high scholarly productivity but also pioneering contributions to biomedical science and engineering

Zhejiang University | China

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🎓Early Academic Pursuits 

Education and Training

Linghui Qian’s journey into the world of pharmaceutical sciences began with her undergraduate education at Zhejiang University, one of China’s most prestigious institutions. From September 2008 to June 2012, she pursued a Bachelor of Science in Pharmaceutical Science at the College of Pharmaceutical Sciences. During this period, she cultivated a strong foundation in drug metabolism and pharmaceutical analysis, which would later define her research trajectory. Under the mentorship of Prof. Su Zeng, she explored fundamental principles that underpin the development of chemical tools used in biomedical research. Driven by a passion for scientific inquiry, Linghui Qian advanced her studies internationally. In January 2013, she enrolled in the National University of Singapore (NUS) for a Ph.D. in Chemical Biology at the Department of Chemistry. Under the guidance of Prof. Shao Qin Yao, she worked on interdisciplinary projects that bridged chemistry and biology, especially focusing on chemical tools to probe biological systems. Her doctoral research laid the groundwork for her interest in the development of fluorescent probes and the functionalization of antibodies for disease-targeted applications.

💼Professional Endeavors 

Academic Positions

Following her Ph.D., Linghui Qian undertook several impactful research roles that broadened her scientific perspective and allowed her to apply her academic learnings in cutting-edge research environments. Between January 2017 and August 2017, she served as a Research Assistant at the Department of Chemistry, NUS, continuing to collaborate with Prof. Shao Qin Yao. She deepened her understanding of live-cell imaging, biomolecular detection, and the modulation of biological processes using synthetic tools. From September 2017 to September 2018, she moved to Singapore’s A*STAR (Agency for Science, Technology and Research), where she held the position of Research Fellow at the Institute of Molecular and Cell Biology. Under the supervision of Prof. Haiwei Song, she expanded her research scope, delving into molecular mechanisms of disease and exploring ways to harness chemical biology for therapeutic applications. In November 2018, she returned to her alma mater, Zhejiang University, as a tenure-track Research Professor at the College of Pharmaceutical Sciences. This appointment marked the beginning of a new chapter in her professional journey, where she leads independent research and mentors the next generation of scientists.

📚Contributions and Research Focus on Fluorescent imaging

Linghui Qian is recognized for her significant contributions to chemical biology and pharmaceutical sciences. Her research focuses on the development and application of innovative chemical probes to detect and study biomacromolecules in live systems. These tools are critical in understanding complex biological phenomena, especially those related to disease. Her work is particularly centered on Development of fluorescent probes for live-cell imaging and Functionalization of antibodies for therapeutic applications In addition to tool development, she also explores chemical strategies to regulate biological processes, which has implications for drug development and disease treatment.

🏆Accolades and Recognition 

Though specific awards are not listed in the provided content, Linghui Qian’s rapid career progression—from Ph.D. candidate to Research Professor—within a span of less than a decade speaks volumes about the recognition of her expertise within the academic and scientific communities. Being appointed to a tenure-track position at Zhejiang University, one of China’s top research institutions, reflects her standing as a leading researcher in her field.

🌍 Impact and Influence 

Community Impact

Linghui Qian’s work resides at the intersection of chemical innovation and biological discovery, a space increasingly vital in addressing global health challenges. Her research on chemical probes contributes to a deeper understanding of disease biology, while her advances in antibody functionalization hold potential for therapeutic innovation. Moreover, her experience across top institutions—Zhejiang University, NUS, and A*STAR—demonstrates her global influence and collaboration. As a mentor and educator, she shapes the future of pharmaceutical sciences, fostering interdisciplinary research among students and colleagues.

🔮Legacy and Future Contributions 

With a clear vision and a strong academic foundation, Linghui Qian is poised to leave a lasting legacy in chemical biology and drug discovery. Her continued efforts in developing next-generation imaging tools and therapeutic strategies will likely lead to breakthroughs in understanding and treating diseases such as cancer, neurodegenerative disorders, and infectious diseases. She is also likely to contribute to policy and curriculum development within Zhejiang University, nurturing a vibrant research environment and promoting international scientific collaboration.

 

Conclusion

Linghui Qian’s academic journey and professional contributions showcase a remarkable blend of scholarly excellence, innovative research, and scientific leadership. From her early days at Zhejiang University to her postdoctoral research in Singapore and her current role as a Research Professor, she has consistently pushed the boundaries of pharmaceutical sciences. Her focus on developing fluorescent probes, antibody functionalization, and chemical tools for biological regulation places her at the forefront of chemical biology. As her research continues to evolve, so will her impact on global health and biomedical innovation, making her a name to watch in the years ahead.

📚Publications

A modular artificial intelligence framework to facilitate fluorophore design

Authors: Yuchen Zhu; Jiebin Fang; Shadi Ali Hassen Ahmed; Tao Zhang; Su Zeng; Jia-Yu Liao; Zhongjun Ma; Linghui Qian

Journals: Nature Communications

Catalytic stereodivergent and simultaneous construction of axial and point chirality

Authors: Wen-Tao Wang; Sen Zhang; Wenxuan Lin; Zhang-Hong Luo; Dan Hu; Fen Huang; Ruopeng Bai; Yu Lan; Linghui Qian; Jia-Yu Liao

Journals: Organic Chemistry Frontiers

Autophagy‐Mediated Targeted Protein Degradation

Authors: Jinning Shao; Shangzhi Xie; Shurui Hong; Linghui Qian

Journals: ChemMedChem

Visualizing the cellular internalization of therapeutic antibodies via pH-sensitive release of AIEgen

Authors: Zai-Gang Han; Kaifeng He; Yi Zheng; Linghui Qian

Journals: Organic & Biomolecular Chemistry

Antibody-based near-infrared fluorogenic probes for wash-free imaging of cell-surface proteins

Authors: Haoting Wang; Jiaqi Yan; Wenchao Wang; Endong Chen; Di Chen; Su Zeng; Quan Li; Linghui Qian

Journals: Analytica Chimica Acta
Linghui Qian | Fluorescent imaging | Best Researcher Award

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